【导师简介】吴大强
发布人:中西医结合学院  发布时间:2018-08-10   浏览次数:13


吴大强,男,19846月生,博士,副教授,主要研究方向是中药及其有效成分抑制病原微生物尤其是生物被膜形成和调节肠道菌群的机制研究。2012年以校聘副教授引进加入安徽中医药大学中西医结合临床学院,开展教学科研工作。工作以来,积极融入课题组研究工作中,主持国家自然科学基金青年项目一项,安徽省高校自然科学重点项目一项,安徽中医药大学引进人才基金一项和自然基金青年项目一项,作为主要参加人参加国家级和省级科研项目多项。截止目前共发表相关SCI论文共十余篇,熟悉分子生物学与细菌学试验技术,肠道菌群生物信息学分析等。欢迎研究生加入课题团队,开展科研工作。

1、受教育经历

2009/09-2012/09上海交通大学,生命科学与技术学院,博士

2005/09-2008/07安徽农业大学,林学与园林学院,硕士

2001/09-2005/07安徽农业大学,林学与园林学院,学士

2、研究工作经历

2016/11-至今 安徽中医药大学,中西医结合学院,副教授

2013/7-2016/11安徽中医药大学,中西医结合临床学院,讲师

2012/09-2013/6,安徽中医药大学,中西医结合临床学院,助教

3、主持科研项目(课题)情况

1)国家自然科学基金青年项目, 81503115,鱼腥草素钠抑制铜绿假单胞菌Las菌群传感调控系统的分子机制研究,2016/01-2018/12,17.9万元,在研,主持 ;

2)安徽省高校自然科学研究重点项目,KJ2015A139,鱼腥草素钠抑制铜绿假单胞菌Las菌群传感调控系统的机制研究、2015/01-2016/12,6万元,结题,主持;

3)安徽中医药大学青年自然科学研究基金,2014qn007,鱼腥草素钠抑制铜绿假单胞菌多重耐药株信号分子合成控制生物膜和耐药性形成的研究,2014/01-2015/120.5万元,结题,主持;

4)安徽中医药大学引进人才基金,2013RC003,临床分离铜绿假单胞菌耐药株的附加基因组岛的分析研究,2013/03-2015/123万元,结题,主持。

4.主要论著

1Daqiang Wu, Weifeng Huang, Qiangjun Duan, Huijuan Cheng. Effect of sodium houttuyfonate on symptom pattern of lung-Qi deficiency in rats induced by bacterial biofilm infection. Journal of Traditional Chinese Medicine, 2016, 15;36(6):730-736

2Daqiang Wu, Weifeng Huang, Qiangjun Duan, Fang Li, Huijuan Cheng. Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa. Front Microbiol. 2014; 5: 635.

3Weifeng Huang, Qiangjun Duan, Fang Li, Huijuan Cheng. Daqiang Wu. Sodium houttuyfonate and EDTA-Na in combination effectively inhibits Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans in vitro and in vivo. Bioorg Med Chem Lett. 2014; 25(1): 142-147. (共同通讯作者)

4Da-Qiang Wu, Jing Ye, Hong-Yu Ou, Xue Wei, Xianqing Huang, Ya-Wen He and Yuquan Xu. Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18. BMC Genomics, 2011,12:438.

5Da-Qiang Wu, Yaqian Li and Yuquan Xu. Comparative analysis of temperature-dependent transcriptome of Pseudomonas aeruginosa strains from rhizosphere and human habitats. Applied Microbiology and Biotechnology, 2012,96:1007–1019.

6Da-Qiang Wu, Huijuan Cheng, Changzhong Wang, Changfeng Zhang, Yang Wang, Jing Shao and Qiangjun Duan. Genome Sequence of Pseudomonas aeruginosa Strain AH16, Isolated from a Patient with Chronic Pneumonia in China. Journal of Bacteriology, 2012,194(21):5976-5977.

7Da-Qiang Wu, Huijuan Cheng, Weifeng Huang, Qiangjun Duan. Sodium houttuyfonate in vitro inhibits the biofilm formation and alginate biosynthesis gene expression of Pseudomonas aeruginosa clinical strain. Experimental and Therapeutic Medicine201510:753-758

8吴大强*,黄卫锋,段强军,程惠娟,汪长中,鱼腥草素钠抑制铜绿假单胞菌致病相关运动能力的研究,中国中药杂志,2015408):1585-1588

9Xue Wei, Xianqing Huang, Lulu Tang, Daqiang Wu, Yuquan Xu. Global Control of GacA in Secondary Metabolism, Primary Metabolism, Secretion Systems, and Motility in the Rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology 2013, 195(15): 3387-3400.

10Li-hua Tang , Hua-hua Jian , Chun-yan Song , Da-peng Bao, Xiao-dong Shang , Da-qiang Wu, Qi Tan, Xue-hong Zhang. Transcriptome analysis of candidate genes and signaling pathways associated with light-induced brown film formation in Lentinula edodes. Applied Microbiology and Biotechnology2013)97:4977–4989

11Jing Shao, Huijuan Cheng, Changzhong Wang, Daqiang Wu, Xiaoli Zhu, Lingling Zhu, Zhenxin Sun. Sodium houttuyfonate, a potential phytoanticipin derivative of antibacterial agent, inhibits bacterial attachment and pyocyanine secretion of Pseudomonas aeruginosa by attenuating flagella-mediated swimming motility. World Journal of Microbiology and Biotechnology2013 ,29(12):2373-2378.

12Yaqian Li, Xilin Du, Zhi John Lu, Daqiang Wu, Yilei Zhao, Bin Ren, Jiaofang Huang, Xianqing Huang, Yuhong Xu, Yuquan Xu. Regulatory feedback loop of two phz gene clusters through 5’-untranslated regions in Pseudomonas sp.M18.PLoS One, ,20116:e19413